Lawrence L. Weed received his MD from Columbia University. He has held positions at Yale, the University of Pennsylvania, Case Western Reserve, the Columbia branch of Bellevue Hospital, Walter Reed Army Medical Center, Johns Hopkins Hospital, and Eastern Maine General Hospital. In 1969, he joined the faculty at the University of Vermont. His research focus is primarily on information gathering in medicine, but he has also spent considerable time researching nucleic acids.

Dr. Weed is known as the "father of the problem-oriented medical record (POMR)," which he developed along with subjective, objective, analytical, and planning (SOAP) progress notes. The POMR is a key concept in medical informatics, providing a way to audit medical records by focusing not only on what was done, but why. The POMR and SOAP notes have been adopted by countless healthcare professionals and major medical institutions.

From 1969 to 1982, Dr. Weed worked on the Problem-Oriented Medical Information System (PROMIS) project, which implemented a computerized version of the POMR at the Medical Center Hospital of Vermont.

According to Dr. Weed, the core problem with modern healthcare is that the human brain cannot process the sheer volume of information required to properly care for a patient in the short time available. In 1982, he founded PKC Corporation to make computerized "knowledge coupling" tools that address that very problem.